Microfluidic-assisted synthesis of multifunctional iodinated contrast agent polymeric nanoplatforms

Abstract Contrast Induced Nephropathy is the most severe side-effect arising after non-ionic iodinated contrast agents (CAs) intravenous administration. The use of antioxidants (i.e., N-Acetylcysteine; NAC) one attempted prevention approaches. Herein, we describe microfluidic-assisted synthesis polymeric nanoparticles (NPs) as new multifunctional blood pool CA. aim this research to co-encapsulate Iohexol (IOX; CA) and NAC (preventive agent) into poly-D,L-lactide-co-glycolide (PLGA) PEGylated-PLGA (PLGA-PEG) NPs exploit CA diagnostic proprieties preventing antioxidant activity. A nanoprecipitation protocol has been set-up for PLGA PLGA-PEG NPs, evaluating effect formulation microfluidic parameters by analysing size, PDI IOX encapsulation efficiency. optimized (PLGA-PEG, L:G 50:50, 5% PEG, Mw 90 kDa) formulated with a size 67 ± 2.8 nm